Analysis Note

ControlTested by Western Blot on HEK293 cell lysate.

Application

MAML1 can be detected at 1/1000 dilution in 10 µg of HEK293 cell Lysate.

Research CategoryNeuroscience

Research Sub CategoryDevelopmental Neuroscience

This Anti-MAML1 Antibody is validated for use in WB for the detection of MAML1.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Members of the evolutionarily conserved Mastermind (MAM) protein family, including the three related mammalian Mastermind-like (MAML) proteins MAML1–3, function as crucial coactivators of Notch-mediated transcriptional activation. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway.

Immunogen

Synthetic Linear Peptide.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Physical form

Serum with 0.05% NaN₃

Quality

Routinely evaluated by immunoblot.

Specificity

Cat. # AB15546 recognizes MAML1 protein.

Reactivity with other species has not been tested.

Storage and Stability

Maintain at -20°C in undiluted aliquots for up to 1 year after date of receipt.

Target description

108 kDa